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Cryopreservation in Cell Therapy Workflows: Overcoming the Limitations of DMSO-Based Formulations

Cryopreservation is a crucial step in cell therapy workflows, ensuring the long-term viability and availability of therapeutic cells. However, the use of traditional dimethyl sulfoxide (DMSO) cryoprotectants presents challenges due to associated toxicities. This article highlights the importance of cryopreservation in cell therapy, examines the potential harms of DMSO, and discusses relevant studies that shed...

Introduction to the Cell Therapy Workflow

Allogeneic Workflow: In the allogeneic approach, immune cells are sourced from healthy donors or established cell banks rather than the patient themselves. These donor cells are carefully selected and expanded in large quantities under controlled laboratory conditions. The expanded cells are then modified or activated to enhance their therapeutic properties, such as targeting specific disease markers...

Chemically Induced Extracellular Ice Nucleation Reduces Intracellular Ice Formation Enabling 2D and 3D Cellular Cryopreservation